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Research Highlight

Inoue and Zhang,
Science 2011
Replication-dependent loss of 5hmC in mouse preimplantation embryos

Photo Credit: Azusa Inoue
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Research Interests


A blastocyst embryo stained with Oct4 and Cdx2 antibodies



Photo Credit: Azusa Inoue
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Research Interests


A primary human islet stained with Insulin, Glucagon and PDX1 antibodies


Photo Credit: Wei Jiang
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Research Interests


Mouse embryos at different developmental stages



Credit: Inoue and Yamaguchi
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Research Interests


In vitro cultured cortical neurons




Photo Credit: Tao and Wu
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Research Interests


Staining of a mitotic MII oocyte with tubulin, H4K20me3, and CREST antibodies


Photo Credit: Azusa Inoue
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Research Highlight

Yamaguchi et al.,
Nature 2012
Tet1 controls meiosis by regulating meiotic gene expression

"Univalent chromosomes in Tet1-deficient female germ cells"
Photo Credit: Shinpei Yamaguchi
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Research Highlight

Yamaguchi et al.,
Nature 2013
Role of Tet1 in genomic imprinting erasure

"The E10.5 Tet1-paternal knockout embryo (right) shows placenta malformation and embryonic defects"
Photo Credit: Shinpei Yamaguchi
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Research Highlight

Inoue et al.,
Nat. Struct. Mol. Biol. 2014
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes

"TEM image of the nucleosome-depleted nucleus in mouse zygotes"
Photo Credit: Azusa Inoue
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Figure of the Month

Matoba et al.,
Cell 2014
Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation

A Model Illustrating How the H3K9me3 Reprogramming Barrier Can Be Overcome

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  Announcements   Recent Publications   Recent News  
  »    Zhang labs received the Klarman Family Foundation Grant in Eating Disorders Research.
July, 2014    

»    Welcome to Dr. Luis M. Tuesta!
Jan, 2014    

»    Welcome to graduate student Xiaoji Wu!
Aug, 2013    

»    Welcome to Drs. Xiang Ma, Wen Yuan, and Yuting Liu!
Jan, 2013    

»    Congratulations to Shinpei Yamaguchi and Shogo Matoba, both receiving JSPS Postdoctoral Fellowship for Research Abroad
Oct, 2012    

  » Matoba, S., Liu, Y., Lu, F., Iwabuchi, K.A., Shen, L., Inoue, A., and Zhang, Y. (2014). Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation.
Cell 159, 884–895. »

» Wu, H., Wu, X., Shen, L., and Zhang, Y. (2014). Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing.
Nat Biotechnol. 32, 1231–1240 »

» Shen, L., Inoue, A., He, J., Liu, Y., Lu, F., and Zhang Y. (2014). Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes.
Cell Stem Cell. 15, 459–470. »

» Lu, F., Liu, Y., Jiang, L., Yamaguchi, S., and Zhang, Y. (2014). Role of Tet proteins in enhancer activity and telomere elongation.
Genes Dev. 28, 2103-2119. »

  » Removing roadblocks to therapeutic cloning to produce stem cells »
Nov, 2014    

» Study identifies protein that helps developing germ cells wipe genes clean of past imprints »
Dec, 2013    

» Biomarker could help scientists choose the right cell line when conducting stem cell experiments »
June, 2013    

» Mutation Linked to Male Infertility »
June, 2013    

» Epizyme, a cancer drug company funded based on the IPs from the Zhang lab, has successfully completed IPO »
June, 2013    

 
 
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