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Research Highlight

Inoue and Zhang,
Science 2011
Replication-dependent loss of 5hmC in mouse preimplantation embryos

Photo Credit: Azusa Inoue
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Research Interests


A blastocyst embryo stained with Oct4 and Cdx2 antibodies



Photo Credit: Azusa Inoue
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Research Interests


A primary human islet stained with Insulin, Glucagon and PDX1 antibodies


Photo Credit: Wei Jiang
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Research Interests


Mouse embryos at different developmental stages



Credit: Inoue and Yamaguchi
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Research Interests


In vitro cultured cortical neurons




Photo Credit: Tao and Wu
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Research Interests


Staining of a mitotic MII oocyte with tubulin, H4K20me3, and CREST antibodies


Photo Credit: Azusa Inoue
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Research Highlight

Yamaguchi et al.,
Nature 2012
Tet1 controls meiosis by regulating meiotic gene expression

"Univalent chromosomes in Tet1-deficient female germ cells"
Photo Credit: Shinpei Yamaguchi
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Research Highlight

Yamaguchi et al.,
Nature 2013
Role of Tet1 in genomic imprinting erasure

"The E10.5 Tet1-paternal knockout embryo (right) shows placenta malformation and embryonic defects"
Photo Credit: Shinpei Yamaguchi
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Research Highlight

Inoue et al.,
Nat. Struct. Mol. Biol. 2014
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes

"TEM image of the nucleosome-depleted nucleus in mouse zygotes"
Photo Credit: Azusa Inoue
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Figure of the Month

Matoba et al.,
Cell 2014
Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation

A Model Illustrating How the H3K9me3 Reprogramming Barrier Can Be Overcome

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  Announcements   Recent Publications   In the News  
  »    Welcome to our new Postdoc, Nadhir Djekidel!
Oct, 2016    

»     The Zhang Lab has been renewed for 5 years of Howard Hughes Medical Institute funding!
Aug, 2016    

»    Welcome to our new lab manager, Ms. Jennifer Ballew!
Apr, 2015    

»    Welcome to Drs. Ren-Chao Chen, Minchul Kim, and Tsukasa Suzuki!
Feb, 2015    

»    The Zhang lab received the Klarman Family Foundation Grant in Eating Disorders Research.
July, 2014    

»    Welcome to Dr. Luis Tuesta!
Jan, 2014    

»    Welcome to graduate student Xiaoji Wu!
Aug, 2013    

  » Lu, F., Liu, Y., Inoue, A., Suzuki, T., Zhao, K., and Zhang, Y. (2016) Establishing Chromatin Regulatory Landscape during Mouse Preimplantation Development.
Cell 165, 1375-1388. »

» Wu, H., Wu, X., and Zhang, Y. (2016) Base-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seq.
Nature Protocols 11, 1081-1100. »

» Chung, Y.G., Matoba, S., Liu, Y, Cha, K.Y., Lee, D.R., and Zhang, Y. (2015) Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.
Cell Stem Cell 17, 758 - 766. »

» Jiang, H., Xu, Z., Zhong, P., Ren, Y., Liang, G., Schilling, H.A., Hu, Z., Zhang, Y., Wang, X., Chen, S., Yan, Z., and Feng, J., (2015) Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature Communications 6, 10100. »

» Wu, H. and Zhang, Y (2015) Charting oxidized methylcytosines at base resolution.
Nat Mol Struct Bio 9, 656-661. »

» Lu, F., and Zhang, Y. (2015). Cell totipotency: molecular features, induction, and maintenance.
National Science Review 2, 217-225. »

  » Removing roadblocks to therapeutic cloning to produce stem cells »
Nov, 2014    

» Study identifies protein that helps developing germ cells wipe genes clean of past imprints »
Dec, 2013    

» Biomarker could help scientists choose the right cell line when conducting stem cell experiments »
June, 2013    

» Mutation Linked to Male Infertility »
June, 2013    

» Epizyme, a cancer drug company funded based on the IPs from the Zhang lab, has successfully completed IPO »
June, 2013    

 
 
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