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Research Highlight

Inoue and Zhang,
Science 2011
Replication-dependent loss of 5hmC in mouse preimplantation embryos

Photo Credit: Azusa Inoue
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Research Interests


A blastocyst embryo stained with Oct4 and Cdx2 antibodies



Photo Credit: Azusa Inoue
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Research Interests


A primary human islet stained with Insulin, Glucagon and PDX1 antibodies


Photo Credit: Wei Jiang
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Research Interests


Mouse embryos at different developmental stages



Credit: Inoue and Yamaguchi
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Research Interests


In vitro cultured cortical neurons




Photo Credit: Tao and Wu
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Research Interests


Staining of a mitotic MII oocyte with tubulin, H4K20me3, and CREST antibodies


Photo Credit: Azusa Inoue
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Research Highlight

Yamaguchi et al.,
Nature 2012
Tet1 controls meiosis by regulating meiotic gene expression

"Univalent chromosomes in Tet1-deficient female germ cells"
Photo Credit: Shinpei Yamaguchi
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Research Highlight

Yamaguchi et al.,
Nature 2013
Role of Tet1 in genomic imprinting erasure

"The E10.5 Tet1-paternal knockout embryo (right) shows placenta malformation and embryonic defects"
Photo Credit: Shinpei Yamaguchi
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Figure of the Month

Inoue et al.,
Nat. Struct. Mol. Biol. 2014
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes

"TEM image of the nucleosome-depleted nucleus in mouse zygotes"
Photo Credit: Azusa Inoue
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  Announcements   Recent Publications   Recent News  
  »    Welcome to graduate student Xiaoji Wu!
Aug 15, 2013    

»    Big welcome to Drs. Xiang Ma, Wen Yuan, and Yuting Liu!
Jan 17, 2013    

»    Congratulations to Shinpei Yamaguchi and Shogo Matoba, both receiving JSPS Postdoctoral Fellowship for Research Abroad
Oct 9, 2012    

»    Student, postdoc and
technician positions are
available for the studies of
epigenetic regulation in
development, stem cell,
reward-related learning and memory »
Jul 4, 2012    

  » Shen, L., Song, C.-X., He, C., and Zhang, Y. (2014). Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation.
Annu. Rev. Biochem. 83, 585–614. »

» Inoue, A., and Zhang, Y. (2014). Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes.
Nature Structural & Molecular Biology. In Press. »

» Li, X., Wei, W., Zhao, Q.Y., Widagdo, J., Baker-Andresen, D., Flavell, C.R., D'Alessio, A., Zhang, Y., and Bredy, T.W. (2014). Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation.
PNAS 111, 7120–7125. »

» Tuesta, L.M., and Zhang, Y. (2014). Mechanisms of epigenetic memory and addiction.
EMBO J. 33, 1091-1103. »

  » Study identifies protein that helps developing germ cells wipe genes clean of past imprints »
Dec, 2013    

» Biomarker could help scientists choose the right cell line when conducting stem cell experiments »
June, 2013    

» Mutation Linked to Male Infertility »
June, 2013    

» Epizyme, a cancer drug company funded based on the IPs from the Zhang lab, has successfully completed IPO »
June, 2013    

» Zhang labs received funds to study epigenetic mechanism of brain reward and drug addiction »
Oct, 2012    

 
 
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