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Research Highlight

Inoue and Zhang,
Science 2011
Replication-dependent loss of 5hmC in mouse preimplantation embryos

Photo Credit: Azusa Inoue
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Research Interests


A blastocyst embryo stained with Oct4 and Cdx2 antibodies



Photo Credit: Azusa Inoue
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Research Interests


A primary human islet stained with Insulin, Glucagon and PDX1 antibodies


Photo Credit: Wei Jiang
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Research Interests


Mouse embryos at different developmental stages



Credit: Inoue and Yamaguchi
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Research Interests


In vitro cultured cortical neurons




Photo Credit: Tao and Wu
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Research Interests


Staining of a mitotic MII oocyte with tubulin, H4K20me3, and CREST antibodies


Photo Credit: Azusa Inoue
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Research Highlight

Yamaguchi et al.,
Nature 2012
Tet1 controls meiosis by regulating meiotic gene expression

"Univalent chromosomes in Tet1-deficient female germ cells"
Photo Credit: Shinpei Yamaguchi
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Figure of the Month

Yamaguchi et al.,
Nature 2013
Role of Tet1 in genomic imprinting erasure

"The E10.5 Tet1-paternal knockout embryo (right) shows placenta malformation and embryonic defects"
Photo Credit: Shinpei Yamaguchi
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  Announcements   Recent Publications   Recent News  
  »    Welcome to graduate student Xiaoji Wu!
Aug 15, 2013    

»    Big welcome to Drs. Xiang Ma, Wen Yuan, and Yuting Liu!
Jan 17, 2013    

»    Congratulations to Shinpei Yamaguchi and Shogo Matoba, both receiving JSPS Postdoctoral Fellowship for Research Abroad
Oct 9, 2012    

»    Student, postdoc and
technician positions are
available for the studies of
epigenetic regulation in
development, stem cell,
reward-related learning and memory »
Jul 4, 2012    

  » Wu, H., and Zhang, Y. (2014). Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions.
Cell. 156, 45-68. »

» Wang, Y., Zhang, Y. (2014). Regulation of TET Protein Stability by Calpains.
Cell Reports. In Press. »

» Yamaguchi, S., Shen, L., Liu, Y., Sendler, D., and Zhang, Y. (2013). Role of Tet1 in genomic imprinting erasure.
Nature. 504, 460-464. »

» Kohli, R.M., Zhang, Y. (2013) TET enzymes, TDG and the dynamics of DNA demethylation.
Nature. 502, 472–479. »

» Ran, F.A., Hsu, P.D., Lin, C.Y., Gootenberg, J.S., Konermann, S., Trevino, A.E., Scott, D.A., Inoue, A., Matoba, S., Zhang, Y., Zhang, F. (2013). Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity.
Cell. 154, 1380–1389. »

  » Study identifies protein that helps developing germ cells wipe genes clean of past imprints »
Dec, 2013    

» Biomarker could help scientists choose the right cell line when conducting stem cell experiments »
June, 2013    

» Mutation Linked to Male Infertility »
June, 2013    

» Epizyme, a cancer drug company funded based on the IPs from the Zhang lab, has successfully completed IPO »
June, 2013    

» Zhang labs received funds to study epigenetic mechanism of brain reward and drug addiction »
Oct, 2012    

 
 
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