Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.H., Ito, S., Yang, C., Wang, P., Xiao, M.T., Liu, L.X., Jiang, W.Q., Liu, J., Zhang, J.Y., Wang, B., Frye, S., Zhang, Y., Xu, Y.H., Lei, Q.Y, Guan, K.L., Zhao, S.M., Xiong, Y. (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketogluterate-dependent dioxygenases. Cancer Cell. 19(1):17-30.
Nguyen, A.T., Xiao, B., Neppl, R.L., Kallin, E.M., Li, J., Chen, T., Wang, D.Z., Xiao, X., Zhang, Y. (2011) DOT1L regulates dystrophin expression and is critical for cardiac function. Genes and Development 25(3):263-74
He, J., Nguyen, A.T., Zhang, Y. (2011) KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood 117(14):3869-3880.
Wu, H.*, D'Alessio, A.C.*, Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Sun, Y.E., Zhang, Y. (2011) Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473(7347):389-393. (* authors contributed equally)
Wu, H., D'Alessio, A.C., Ito, S., Wang, Z., Cui, K., Zhao, K., Sun, Y.E., Zhang, Y. (2011) Genome-wide analysis of 5-hydroxymethylsytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes and Development 25(7):679-84.
Nguyen, A. T., Taranova, O., He, J. & Zhang, Y. (2011) DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood 117(25):6912-6922.
Nguyen, A.T., and Zhang, Y. (2011). The diverse functions of Dot1 and H3K79 methylation. Genes and Development 25(13):1345-1358.
Wu, H., and Zhang, Y. (2011). Tet1 and 5-hydroxymethylation: A genome-wide view in mouse embryonic stem cells. Cell Cycle 10(15):2428-2436.
Wu, S.C., and Zhang, Y. (2011). Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability. J Biol Chem 286(32):28511-28519.
Nguyen, A.T., He, J., Taranova, O., and Zhang, Y. (2011). Essential role of DOT1L in maintaining normal adult hematopoiesis. Cell Res 21(9):1370-1373.
Ito, S.*, Shen, L.*, Dai, Q., Wu, S.C., Collins, L.B., Swenberg, J.A., He, C., and Zhang, Y. (2011). Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333(6047):1300-1303. (* authors contributed equally)
Tao, Y., Neppl, R.L., Huang, Z.P., Chen, J., Tang, R.H., Cao, R., Zhang, Y., Jin, S.W., and Wang, D.Z. (2011). The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol 194(4):551-565.
Inoue, A. and Zhang, Y. (2011). Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos. Science 334(6053):194.
Inoue, A., Shen, L., Dai, Q., He, C., and Zhang, Y. (2011). Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res 21(12):1670-1676.
Wu, H. and Zhang, Y. (2011). Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 25(23):2436-2452
